Most consecutive games played in NHL history — Top 10

first_imgPatrick Marleau is set to become just the sixth player in NHL history to play 800 consecutive games Tuesday when the Sharks play the Chicago Blackhawks. Here are the top 10 longest games-played streaks in league history. Numbers listed are for before Tuesday’s games.Rank    Name           Position    Streak     Start date       End date  1. Doug Jarvis            C               964        10/08/1975    10/10/19872. Garry Unger           C              914         02/24/1968    12/21/19793. …last_img

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Adult Stem Cells Beat Clones

first_img(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0 In a contest to see which are better, induced pluripotent stem cells proved just as good as clones.  More stem cell news follows.Stem cell recipes went head to head, Science Magazine reported, and came out in a tie.  Kelly Servick writes:What’s the best recipe for creating patient-specific stem cells? The question has prompted years of debate and a series of contradictory papers. Ideally, the cells should develop into any cell type just as well as those in a natural embryo do. For now, the 7-year-old method of introducing a small set of genes into adult cells to create so-called induced pluripotent stem (iPS) cells dominates the field. But a few researchers have stuck with an older approach—putting a donor nucleus into an unfertilized egg and deriving stem cells from the resulting embryo. This somatic cell nuclear transfer (SCNT) technique is costly, technically challenging, and ethically fraught on several fronts. But proponents have argued that cells created this way are superior, in part because iPS cells may retain features of mature cells and could acquire a greater number of genetic changes in the reprogramming process. The latest research on the matter, published this week in Cell Stem Cell, examines genetic features of the two cell types and declares a tie.That might surprise some people, because the researcher who led the work, Dieter Egli of the New York Stem Cell Foundation (NYSCF) in New York City, has long been a proponent of nuclear transfer. He gave a preview of the paper on 22 October at the foundation’s annual conference. “This means that all of you who are working on iPS cells are probably working with cells that are actually very good. So I have good news for you,” he told them, eliciting murmurs and chuckles. “What this exactly means for the SCNT program, I don’t know yet.” Indeed, some longtime champions of the nuclear transfer—Egli included—aren’t ready to abandon the method yet.Science Daily reports that the New York Stem Cell Foundation finds the two types of stem cells “very similar” in terms of DNA methylation, mutations, and gene expression patterns.  Since iPS cells are “not ethically fraught” at all, it would seem SCNT should declare no contest.  The articles do not give any clear reason why cloning should be continued; but proponents like Mitalipov are vowing to defend their work.The New York foundation claims that embryonic stem cells are still superior.  “It is important to note that both types of techniques led to cells that had more of these aberrations than embryonic stem cells derived from an unfertilized human oocyte, or than embryonic stem cells derived from leftover IVF embryos,” Science Daily says.  “These findings suggest that a small number of defects are inherent to the generation of stem cells from adult differentiated cells and occur regardless of the method used.”The question becomes whether it is advisable to destroy human embryos to heal those already born into the world, if iPS and adult stem cells are sufficient for therapeutic needs.  If adult stem cells from a 97-year-old  person’s cornea can heal retina damage (10/22/14), why take them from the unborn?  Why not instead, as PhysOrg reported, study how embryos produce their stem cells and use those secrets to reprogram adult cells?  A story in Science Daily shows how researchers are constantly refining methods for iPS, but SCNT-derived stem cells are not without problems.In the meantime, iPS and adult stem cells continue to show great promise for human health.  The smart money goes to ethically-clean methods.Brain injuries in mice treated using bone marrow stem cells, antioxidants (Science Daily): Stem cell treatment combined with drug therapy shows regeneration of brain tissue and the blood vessels supporting them.Reprogramming cells, long term (Science Daily): Harvard scientists “have demonstrated that adult cells, reprogrammed into another cell type in a living animal, can remain functional over a long period.“iPS cells used to understand schizophrenia (Nature): “We showed that mutant DISC1 [a schizophrenia marker] causes synaptic vesicle release deficits in iPS-cell-derived forebrain neurons,” researchers at Johns Hopkins found.  “…Our study reveals that a psychiatric disorder relevant mutation causes synapse deficits and transcriptional dysregulation in human neurons and our findings provide new insight into the molecular and synaptic etiopathology of psychiatric disorders.”Remotely controlled magnetic nanoparticles stimulate stem cells to regenerate bones (PhysOrg): “Medical researchers from Keele University and Nottingham University have found that magnetic nanoparticles coated with targeting proteins can stimulate stem cells to regenerate bone,” the article says. “Researchers were also able to deliver the cells directly to the injured area, remotely controlling the nanoparticles to generate mechanical forces and maintain the regeneration process through staged releases of a protein growth stimulant.”  Presumably the stem cells come from the patient’s own body.Establishment of induced pluripotent stem cells from Werner syndrome fibroblasts (Science Daily): Werner syndrome causes patients to age rapidly; now, “genome editing” of patient-derived stem cells offers new hope.  “Induced pluripotent stem (iPS) cells from Werner Syndrome fibroblasts have been established, scientists report.”Making personalized blood vessels from a patient’s blood sample (Science Daily): Swedish researchers rebuilt blood vessels from blood stem cells, without having to drill into bone marrow, which is painful.Delivery of stem cells into heart muscle after heart attack may enhance cardiac repair and reverse injury (Mt. Sinai Hospital): “A novel SCF gene transfer delivery system induced the recruitment and expansion of adult c-Kit positive (cKit+) cardiac stem cells to injury sites that reversed heart attack damage. In addition, the gene therapy improved cardiac function, decreased heart muscle cell death, increased regeneration of heart tissue blood vessels, and reduced the formation of heart tissue scarring.”Technology to advance stem cell therapeutics patented (Rutgers U): “Our motivation was to develop a highly robust, efficient nanoparticle-based platform that can regulate gene expression and eventually stem cell differentiation,” says Ki Bum-Lee, who developed NanoScript for that purpose.  NanoScript uses gold nanoparticles to mimic the transcription factors that regulate stem cell differentiation.Production of human motor neurons from stem cells gaining speed (PhysOrg): Researchers at the Institute for Stem Cell Therapy are finding new ways to rapidly produce large quantities of human pluripotent stem cells.  “In the medium term, the approach should contribute to the development of treatments for paralytic diseases such as infantile spinal muscular amyotrophy or amyotrophic lateral sclerosis.“Nail stem cells prove more versatile than press-ons (University of Southern California): Think about it; your fingernails grow, don’t they?  That’s because of an “elusive” source of stem cells that produce both nails and skin.  USC researchers made a “surprising discovery,” the press release says; they “identified a new population of nail stem cells, which have the ability to either self-renew or undergo specialization or differentiation into multiple tissues.”What is the ultimate stem cell?  An article on Medical Xpress indicates that embryonic stem cells may not be very much ahead of iPSCs, the stem cells reprogrammed from adult tissues.  Researchers at the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute compared the two.  The director was asked if embryonic stem cells are better:Could naive human ES cells be the stem cell of choice for tissue therapy? “We don’t yet know,” said Smith. “These cells would offer the hope of having a broader and more consistent ability to differentiate into a range of cell types because they are at an earlier stage of development. But it’s also entirely possible that current stem cells are good enough for some applications. The point is, we needed these new stem cells in order to find out what is best.”But those nagging ethical issues remain.  In “The ethical, legal and political minefield of stem cell research,” PhysOrg reminds readers that the “Great Debate” about using human embryos for research “has been the subject of comment, criticism and even court cases.”  With its recounting of the strong opinions voiced on both sides, the patent debates and the ethical outcries over what constitutes a human, the article is a sad reminder of the hand-wringing that still goes on over ESC research.  When there is more than one way to reach a destination, wisdom dictates walking around the minefield when possible.  That’s the path adult stem cell technology takes.Update 11/24/14: Harvard scientists failed to get embryonic stem cells to form neurons, until they tried induced pluripotent stem cells, reports Science Daily.  “I think the ability to make human pain neurons for the pain field is going to be very important,” Clifford Woolf says.  “Furthermore, our failure with embryonic stem cells lead us to work with adult tissue samples making the technology much more clinically relevant since these are easy to collect from patients suffering from different kinds of pain.”  This is important for showing that iPS cells can actually perform better than embryonic stem cells.Can anyone find a really good reason for using human embryos in the burgeoning field of stem cell therapeutics?  The only claim is that they are totipotent, able to generate any tissue in the body, and iPSCs are pluripotent—something less.  Even that argument is not clear, though.  Each new discovery appears to show adult stem cells throughout the body—in the cornea, brain, bone marrow, placenta, mesenchyme, heart and elsewhere—that can be activated in place or relocated where needed.  And then there is reprogramming, using iPSC methods to turn skin cells into stem cells.  The toolkit seems plenty adequate for desired therapies, and it’s getting better all the time.  The burden of proof should be on the SCNT and ESC researchers to show why they deserve any money or respect.last_img read more

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Win tickets to the Confederations Cup!

first_img15 April 2009Get out your phone and stand to win tickets to the Confederations Cup for yourself and three friends: SMS ‘FLAG’ to 41929 (R2 per SMS) or go to mobile website www.flythesouthafricanflag.mobi to enter.The competition is part of “Fly the Flag for Football”, a national campaign to build public support and excitement leading up to the 2009 Fifa Confederations Cup and 2010 World Cup.The 2010 National Communication Partnership, a partnership of organisations involved in communicating about the soccer mega-events being hosted by South Africa, aims to distribute over 47-million South African flags through various campaigns by the time the World Cup kicks off in June 2010.“Our national Flag is a powerful symbol of unity and pride, and we would like to play our part by encouraging South Africans to proudly fly the flag as the eyes of the world are upon us,” Margaret Dingalo of the International Marketing Council of South Africa said ahead of the launch of the campaign last week.“The 2009 Fifa Confederations Cup is starting in less than 100 days, and excitement is building,” Dingalo said. “We need to help drive enthusiasm and patriotism, garnering support among South Africans for Bafana Bafana and the event as a whole.”Colourful face-painted figures wearing South African flag t-shirts and makarapas, the football fan hat that is unique to South Africa, handed out free flags at tollgates, garages and airports across the country over the Easter long weekend.For South African football great Mark Fish, the campaign’s official spokesman, the Confederations Cup and World Cup are about more than football, representing “the opportunity of a lifetime, for South Africa and Africa as a whole.“Let us raise our flags in unity, joining together to make the 2009 Fifa Confederations Cup and 2010 Fifa World Cup joyful, unforgettable events,” Fish said. “Fly your flag and show the world the warmth and spirit of South Africa.”Members of the 2010 National Communication Partnership include the International Marketing Council of SA, South African Tourism, the 2010 Fifa World Cup Local Organising Committee, the Department of Arts and Culture, South African Airways, Proudly South African, and several other private sector and civil society groups.SAinfo reporterWould you like to use this article in your publication or on your website? See: Using SAinfo materiallast_img read more

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5 days agoFernandinho: Ederson superb for Man City win

first_imgAbout the authorPaul VegasShare the loveHave your say Fernandinho: Ederson superb for Man City winby Paul Vegas5 days agoSend to a friendShare the loveFernandinho was happy with Manchester City’s 2-0 win at Crystal Palace.Fernandinho again filled in at centre-half on the day.He said: “We just tried to play our style of football and our philosophy. In the first half we scored two goals and controlled the game but at the end of the game they brought on Benteke and he caused some problems for us but Ederson was superb to make the saves.”They started to play long balls and high balls for their tall players. But if we scored the goals from the chances we created it would have been a different game.”On playing at centre-back, he added: “It was fine. In the first half we controlled out actions and didn’t concede any chances. But in the second half we dropped our concentration but overall we were better and deserved the win.”The Premier League is so tough, so hard, so we just try to win our games and do our job. We focus on winning every game. That is all we can do.” last_img read more

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Jamaica Records Most Successful Winter Tourist Season

first_img The 2018/19 Winter Tourist Season has emerged as Jamaica’s most successful based on earnings and visitor arrivals, Tourism Minister, Hon. Edmund Bartlett, has said. Mr. Bartlett said the boom in visitor arrivals to Jamaica has spurred investment interests, while advising of the impending commencement of several projects to construct thousands of additional hotel rooms islandwide.Meanwhile, the Minister, who emphasised that coffee has several value-added components that are not fully exploited by local entrepreneurs, urged them to explore these and not focus solely on exporting only coffee beans.Noting that there is growing demand for volunteerism, “which will enable you to earn”, Mr. Bartlett said the Volunteer Training Programme afforded the participants an opportunity to explore this.Under the Tourism Linkages Network initiative, which is a partnership with the Tourism Product Development Company, participants are provided with Team Jamaica certification.Minister of Tourism, Hon. Edmund Bartlett (centre, back row), and Executive Director of the Tourism Product Development Company (TPDCo), Dr. Andrew Spencer (fourth left, back row), with several participants in the Jamaica Blue Mountain Coffee Festival Volunteer Training Programme, during an awards ceremony at the University of Technology (UTech) in St. Andrew, on Tuesday (April 16). Mr. Bartlett added that 121,000 persons directly employed in the sector, and another 375 who work indirectly, benefited from this out-turn. The 2018/19 Winter Tourist Season has emerged as Jamaica’s most successful based on earnings and visitor arrivals, Tourism Minister, Hon. Edmund Bartlett, has said.He notes that over the last three months of the season, which commenced on December 15, the industry welcomed nearly 800,000 stopover visitors while generating more than $1 billion in earnings.Mr. Bartlett added that 121,000 persons directly employed in the sector, and another 375 who work indirectly, benefited from this out-turn.“Our growth has been phenomenal. This is the greatest and most productive tourism winter season that Jamaica has ever seen in its history,” the Minister said.He was addressing the gathering at an awards ceremony for the first cohort of graduates under the Jamaica Blue Mountain Coffee Festival Volunteer Training Programme, at the University of Technology (UTech) in St. Andrew on April 16.Minister of Tourism, Hon. Edmund Bartlett (left), converses with several of the participants in the Jamaica Blue Mountain Coffee Festival Volunteer Training Programme, during an awards ceremony at the University of Technology (UTech) in St. Andrew on Tuesday (April 16). He notes that over the last three months of the season, which commenced on December 15, the industry welcomed nearly 800,000 stopover visitors while generating more than $1 billion in earnings. Story Highlights The first cohort included 28 students from UTech and the Edna Manley College of the Visual and Performing Arts.The programme aims to assist coffee farmers to boost production, and provide locals and visitors with experiences highlighting Jamaica’s authentic coffee culture.last_img read more

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